Wageningen UR BSc and MSc Project Database

BSc-MSc Thesis and Internship Projects, Wageningen University

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Helminths as members of the gut microbiome
Parasitic worms (or helminths) are often seen as bad, but after a long history of co-evolution, parasites can modulate the immune system of their host for the better. The old friendâ€™s hypothesis even states that we have become d ...
Supervisor: Stefan Geisen/Ruud Wilbers/Arjen Schots
Department: Nematology, Laboratory of

Advanced LEGO: engineering tailor-made glycans on recombinant worm proteins
Helminths are parasitic worms that have successfully co-evolved with their host immune system to sustain long-term infections. Their successful parasitism is mainly facilitated by modulation of the host immune system via the relea ...
Supervisor: Ruud Wilbers/Arjen Schots
Department: Nematology, Laboratory of

Plant-based production of vaccines against parasitic worms
Parasitic worms (helminths) infect over 1.5 billion people and continuously threaten livestock worldwide. Chronic helminth infections, in both humans and animals, may cause serious health problems ranging from malnutrition, anemia ...
Supervisor: Ruud Wilbers/Arjen Schots
Department: Nematology, Laboratory of

Understanding individual genetic variation underlying human diseases
Current health care increasingly focuses on personalised medicine and understanding the role of individual genetic differences in disease progression. The genetic model organism C. elegans encodes many genes similar to those in hu ...
Supervisor: Jan Kammenga/Lisa van Sluijs
Department: Nematology, Laboratory of

Nematodes as an epidemiological disease model: tracking virus and parasite infections in complex communities
Climate change and urbanisation alter composition of communities through which infectious disease agents such as viruses spread. Although biodiversity losses are thought to increase disease risks, the exact role of intra- and inte ...
Supervisor: Jan Kammenga/Lisa van Sluijs
Department: Nematology, Laboratory of

Disease tolerance and resistance in nematode-plant interactions
Nematode resistance is becoming the corner stone of durable control of plant parasitic nematodes in agricultural settings wordwide. However, for some nematode populations effective resistances are not available, and breeders must ...
Supervisor: Mark Sterken/Aska Goverse/Geert Smant
Department: Nematology, Laboratory of

Superorganisms: the co-evolution of plants and plant parasitic nematodes
Current agricultural measures against plant parasites focus mostly on the use of so-called resistant cultivars. These control populations of soil-borne parasitic nematodes. However, genetic variation in the parasites can overcome ...
Supervisor: Mark Sterken
Department: Nematology, Laboratory of

Understanding nematode parasitism in plants at the molecular level
Plant parasitic nematodes cause substantial economic losses in agricultural production worldwide. Current control measurements, such as resistance genes and pesticides, are not durable or toxic to the environment. Hence, we study ...
Supervisor: Jose Lozano
Department: Nematology, Laboratory of

Illuminating soil biodiversity interactions with links to nutrient cycling and therefore global change
Soil biodiversity is driving major nutrient cycling pathways, particularly that of carbon. In fact, bacteria and fungi underlie most carbon released to the atmosphere and with increasing temperature this process will accelerate su ...
Supervisor: Stefan Geisen/Hans Helder/Wim van der Putten
Department: Nematology, Laboratory of

Examining soil biodiversity in natural systems and their role in plant vegetation dynamics
Soils contain most biodiversity on Earth and drive major functions such as global elemental cycles and plant community changes. However, we still miss most knowledge on the true biodiversity present in soil and the functional impo ...
Supervisor: Stefan Geisen/Hans Helder/Wim van der Putten
Department: Nematology, Laboratory of

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